Affinity maturation-客製化抗體-盟基生物科技股份有限公司

產品橫幅廣告

Affinity maturation

Affinity maturation

Antibody Engineering & Optimization

Affinity maturation

Antibody Affinity Maturation
抗體親和力優化服務

與抗原的親和性能力為抗體的關鍵因子並影響抗體之功能與效力,尤其為抗體藥物的開發扮演相當重要的角色。雖然過去利用雜交瘤技術所產生的抗體,有相對較高的親和力,但這樣的親和力對於治療性抗體仍舊不足的,GenScript的抗體親和性熟化服務,利用獨家專利FASEBA重組蛋白篩選平台,獲得良好的重組蛋白分析,可增加抗體親和力達到最佳的水準,增加抗體藥物的成功機率。





服務特色

●  透過獨家專利FASEBA平台篩選,同時表現量、親和力以及熱穩定條件評估測試
●  有效提高親和力10-100倍
●  只需要4-5個月

Case study
 
1.GenScript's proprietary paratope mapping technology, key residues affecting expression shown in (A) and binding shown in (B) of an antibody, that can be quickly and accurately Identified. Case studies shown here are only for heavy chains.

2.Affinity maturation performed using FASEBA library construction and screening methods to wild-type and positive test binder AS04498. AS04498 affinity is 38 fold increased compare to wild-type IgG and the affinity interval is shorter compare to As04498.